STE Tecpharm delivers a new 50L granulation line for pharmaceutical products in Algeria.
This installation, designed for small productions, is composed of different integrated pieces of equipment with an in-wall design and managed from the same Siemens PC control panel.
High Shear Mixer Granulator. It has automatic lifting of the central agitator, peristaltic dosing pump and integrated conical calibrator. Fluidized Bed Dryer Granulator. With inlet and outlet air treatment systems, vacuum loading system from the in-line granulator, sampling valve, top spray granulation system and vacuum discharge system with integrated calibrator.
The entire installation has been validated with the ATEX II 3GD certificate.
The end result is complete granulation and drying equipment, fully automated to minimize production times, product loss and the risk of cross-contamination.
Now we begin the installation works at the customer’s manufacturing plant and the subsequent technical training.
The confidence in STE Tecpharm is renewed with this new project since, in 2017, this client already acquired an 880L Fluidized Bed Dryer-Granulator, large equipment of optimum performance.
STE Tecpharm completes the delivery of a complete wet granulation line for a pilot plant for the production of solid pharmaceutical forms, located in Spain.
The granulation line consists of different equipment, integrated into a single frame and managed from within the same control panel.
– 50L High-Shear Granulator.
– Calibrator mill for sieving the wet granule.
– Fluidized Bed Dryer 60L.
– Calibrator mill for sieving the dry granule.
– Fully automated loading, transport and unloading systems to avoid cross-contamination and ensuring optimal product transfer.
The entire installation has been validated with the ATEX II certificate.
Once installed in the cleanroom, this set minimizes the space required and provides maximum versatility for development studies and process scalability.
STE Tecpharm delivers wet granulation equipment to a well-known Spanish laboratory specializing in the manufacture of pharmaceutical and nutraceutical solid forms.
This set consists of a High Shear Granulator with a capacity of 200L and a mill calibrator installed at the product outlet of the granulator. The installation was carried out with the ATEX II certificate.
The high shear mixer granulator has been designed to optimize the wet granulation process, transforming a heterogeneous mixture of fine powder into a uniform granulation, with particle size and a higher density, offering an appropriate flow and optimum compatibility, within of a process of short duration and repetition.
It has been fully designed and built by STE in Europe according to the legal requirements and pharmaceutical standards of good manufacturing practices (GMP), with integrated design inside the cleanroom.
Granulation refers to the process in which the primary dust particles are adhered to form larger entities of multiple particles called granules. In this wet granulation process, the granules are formed by the addition of a binder solution. The granulation solution contains a solvent or carrier material that must be volatile so that it can be removed by drying and not being toxic. Typical liquids include water, ethanol, and isopropanol alone or in combination. The liquid solution may be aqueous or solvent-based. Aqueous solutions have the advantage of being safer to treat than other solvents. The granulation process combines one or more dust particles and forms a granule that will allow the formation of tablets within the required limits. In this way a predictable and repeatable process is possible and quality tablets can be produced using STE TECPHARM technology.
STE Tecpharm introduces a new coating system called OPTIMA COATING SYSTEM. This perforated drum technology increases the batch size range from 10% to 100% and optimizes the parameter adjustment automatically.
On May 14th, 15th and 16th, STE opened its doors to a selection of customers interested in this new totally safe coating technology, designed in a way that the operator does not have to manipulate the equipment.
Among many of the advantages offered by the TP R OPTIMA are:
• Maximum flexibility batch range • Automatic adjustment depending on the level of charge • Arm driven by 2 motors • Automatic flaps to regulate exhaust air • In wall design
More than 50 clients from all over the world visited the STE facilities in Barcelona and have had the opportunity to see the new coating system working at full capacity. During the day two tests were carried out, one with 30KG of product (oblong tablets), and one of 300KG, so customers have witnessed live the flexibility of the TP R OPTIMA to cover batch sizes with weighings in the same equipment so different. All the tests have been successful! Obtaining a very good valuation by the clients.
In this way, STE Tecpharm completes its range of TP R products (COATERS) offering the highest quality and versatility in the world of solid coating.
STE Tecpharm delivers a 5,000L double cone solid mixer to a pharmaceutical manufacturer in Spain, specializing in contract manufacturing of both liquids and solid forms. This equipment, consisting of the mixer and the work platform, has been integrated into a clean room and is part of the facility’s expansion plan to improve plant productivity.
The double cone mixer has been specially designed to produce a smooth and fluid mixture of solid and powdery products, moving an equal amount of particles by gravitational force. It mixes in very short cycles and its design and finishes allow a quick discharge and cleaning.
STE Tecpharm delivers a new tablet coater with a perforated pan to an important Moroccan pharmaceutical laboratory, specialized in the development and manufacture of solid dosage forms that include effervescent tablets, oral disintegration tablets, and water-soluble granules.
The manufactured equipment has a working capacity of 150Kg per batch.
The system is controlled from a touch screen located on the front of the device, which allows manual or automatic operation (Touch Screen Panel + PLC + SIEMENS Industrial PC).
■ Mobile coating arm for easy adjustment and maintenance.
■ Schlick guns to ensure perfect spraying.
■ Automatic download device.
It incorporates a WIP automatic washing system.
The equipment has been certified in accordance with the ATEX standard for the 2GD zone.